Forrester Advice on Hadoop: Best Practices for Early Adopters

first_img3 Areas of Your Business that Need Tech Now IT + Project Management: A Love Affair joe brockmeier 1 Related Posts Tags:#Analysis#enterprise#news center_img Massive Non-Desk Workforce is an Opportunity fo… Hadoop seems to be on everyone’s minds this year. It’s certainly a hot topic for Forrester’s James Kobielus, who’s recently released several reports on Hadoop – including a best practices guide aimed at enterprises. Hadoop is still pretty young, so Kobielus first starts with a couple of challenges facing early adopters. The big challenges, according to Kobielus? An immature market, evolving core specifications, a need for custom coding and a lack of a widely adopted “stack” for Hadoop.Does this sound at all familiar? If you followed the early days of Linux, you should be feeling a bit of Déjà vu here, because this was exactly the sort of thing analysts were saying around 1999 to 2002 (give or take) about Linux. It’s not wrong, per se, but it shouldn’t stand in the way of adoption. Best PracticesThat said, Kobielus does have some good advice for best practices when adopting Hadoop. For example, Kobielus says that companies need to build staff skills – even a “center of excellence” that has training with MapReduce and connections to the Hadoop community. He also waves companies away from “science projects” with Hadoop, or adoption that lacks business value. In short – don’t jump on the Hadoop bandwagon just because it’s the Next Big Thing. Another recommendation from Kobielus that companies should heed is to avoid “overbuilding” the Hadoop cluster if a smaller cluster does the job. And make sure that you can combine Hadoop “silos” at a later date. Says Kobielus, “most of these companies’ Hadoop clusters implement a common stack of Hadoop subprojects, from the storage layer on up. This architectural approach facilitates subsequent convergence of silos as well as easy promotion of MapReduce and other jobs between the silos. Yahoo, in particular, has architected its Hadoop clusters to minimize the interoperability glitches that might result from silos.”And if you don’t have the in-house expertise, Kobielus guides companies towards cloud/Software-as-a-Service (SaaS) providers like Amazon and Appistry. If you want in-house control, but lack expertise, there’s also a slew of commercial options – but you’ll need to do plenty of research before settling on one.No doubt, quite a few ReadWriteEnterprise readers have had some hands-on experience with Hadoop in production already. I’d be curious what best practices you have to share. Cognitive Automation is the Immediate Future of…last_img read more

IPL 2019: Virat Kohli fined Rs 12 lakh for slow over-rate during KXIP vs RCB

first_imgadvertisement No data available! commentary IPL 2019: Virat Kohli fined Rs 12 lakh for slow over-rate during KXIP vs RCBVirat Kohli, who led Royal Challengers Bangalore to their first win on Saturday in Mohali, was fined for slow over-rate after the team’s first offense of the season. scorecardcenter_img graphs view more view less Indo-Asian News Service MohaliApril 14, 2019UPDATED: April 14, 2019 09:39 IST IPL 2019: Virat Kohli led Royal Challengers Bangalore to their first win of the season on Saturday ( Courtesy by BCCI)HIGHLIGHTSVirat Kohli was fined Rs 12 lakh for slow over-rate on SaturdayKohli led Royal Challengers Bangalore to their first win of IPL 2019 in MohaliKohli led from the front with the bat hitting a 53-ball 67 in RCB’s chase of 174Royal Challengers Bangalore (RCB) captain Virat Kohli has been fined after his team maintained a slow over-rate during their Indian Premier League (IPL) match against the Kings XI Punjab (KXIP) here.As it was his team’s first offence of the season under the IPL’s Code of Conduct relating to minimum over-rate offences, Kohli was fined Rs 12 lakh on Saturday.Bottom-placed RCB finally ended their winning drought in the ongoing season as Kohli’s scintillating 53-ball 67 followed by AB de Villiers (59* off 38) and Marcus Stoinis’ (28* off 16) fruitful knocks guided them to a thumping eight-wicket victory over KXIP at the I.S. Bindra Stadium.It was the 85-run stand between Kohli and de Villers before the South African got involved in a match-winning 46-run partnership with Stoinis which handed Bangalore a much needed win.Defending 174, Punjab bowlers not only failed in getting wickets but also leaked runs as the visitors crossed the line with four balls to spare.Earlier Chris Gayle played a magnificent knock and finished unbeaten on 99 as he managed just a boundary off the last ball of the innings from Mohammed Siraj.Also Read | We let ourselves down in the field, says R Ashwin after KXIP’s 8-wicket loss vs RCBAlso See:For sports news, updates, live scores and cricket fixtures, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for Sports news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAkshay Ramesh Tags :Follow Virat KohliFollow KXIP vs RCBFollow IPL 2019last_img read more

Avance Gas Finds Work for Its Newbuild

first_imgzoom Operator and owner of Very Large Gas Carriers (VLGC) Avance Gas Holding has chartered out its newbuild VLGC Monsoon for a 60-90 days time charter.The Monsoon was delivered on 13 January 2015, together with its sister ship VLGCs Mistral.The Monsoon’s charter is set to commence in early February, at a rate reflecting the freight market at the time of negotiations, Avance Gas said.The name of the charterer was not disclosed.Final talks on a similar charter for Mistral are underway, the company added.Avance Gas has a newbuilding program of six VLGCs.As informed, two more newbuilds are pending delivery. Hull 1073 is expected to be delivered late Q1/2015 and hull 1074 is expected to be delivered mid Q2/2015.last_img read more

Safety Harbor Kids To Host Annual Polo Fundraiser

first_imgMalibu nonprofit, Safety Harbor Kids, partnering with luxury electric car company, Tesla Motors, is raising funds for a worthy cause – education for American orphans, foster and homeless children.The 7th Annual Safety Harbor Kids Polo Fundraiser will be held on September 7th from 1-5pm, in Pacific Palisades, CA.With the British American Business Council and Brits in LA taking part, the event will feature appetizers, lunch, wine tasting, polo matches, open bar, surprise entertainment, a string quartet and vocal performances as well as gift bags and a “best hat” contest. Tesla, whose model S was voted Motor Trend Car of the Year will have a car on display.The venue, the Will Rogers Polo Club, offers breathtaking views from the mountains to the sea, and has been the filming location of many movies including Star Trek IV (William Shatner 1986) and Pretty Woman (Julia Roberts and Richard Gere, 1990). Old Hollywood royalty including Clark Gable, Joan Crawford, Walt Disney, and Gary Cooper also frequented the polo estate formerly owned by 1930’s entertainer Will Rogers.Sponsored by Segno Marketing, Panavision, Elite Island Resorts and The Gold Hedge, red carpet photos will begin at 1pm with polo starting at 2pm. Last year’s attendees included John Savage (Deer Hunter, 1978), Eric Roberts (Dark Knight, 2008) and the beloved Michael Clarke Duncan (Green Mile, 1999). Past supporters also include Reese Witherspoon, Jeremy Piven, Mel Gibson and Jim Belushi.Founded in 2007, Safety Harbor Kids (SHK) is a 501c3 nonprofit formed for the purpose of enriching the lives of parentless and homeless children through education in the areas of college, career, music and the arts. SHK operates with one of the lowest expense ratios in the nation at 40% and serves more than 3,000 at risk youth from group homes and shelters within Los Angeles and Ventura Counties, the United States and Worldwide.To attend or donate visit www.donatetoshk.org for ticket information.Source:PR Newswirelast_img read more

Stars Sign Up For Hand In Hand A Benefit For Hurricane Harvey

first_imgHouston native rapper Bun B has teamed up with SB Projects founder Scooter Braun to present Hand in Hand: A Benefit for Hurricane Harvey Relief telethon to aid those affected by Hurricane Harvey.The one-hour special will be based in Los Angeles with stages in New York, Nashville and a special performance by Country Music icon and Texas native George Strait from his San Antonio benefit concert. Hand in Hand will air live on ABC, CBS, CMT, FOX and NBC on Tuesday, September 12, 8:00-9:00pmEST on the East Coast and replay 8:00-9:00pmPST on the West Coast. The show will also be available internationally via live stream on Facebook, YouTube and Twitter starting at 8:00pmEST during the first broadcast.Hand in Hand will bring the country together to raise funds, spirits and help rebuild Texas in the wake of this unprecedented devastation. Proceeds from the telethon will benefit United Way of Greater Houston, Habitat For Humanity, Save the Children, Direct Relief, Feeding Texas and The Mayor’s Fund for Hurricane Harvey Relief (administered by the Greater Houston Community Fund) through the Hand in Hand Hurricane Relief Fund managed by Comic Relief USA.The broadcast will feature appearances, performances, taped tributes and messages from some of the nation’s biggest stars including George Clooney, Jamie Foxx, Karlie Kloss, Beyonce, Matt Lauer, Rob Lowe, Matthew McConaughey, Norah O’Donnell, Dennis Quaid, Julia Roberts, Kelly Rowland, Adam Sandler, Ryan Seacrest, Michael Strahan, Blake Shelton, Strait, Barbra Streisand, Oprah Winfrey and Reese Witherspoon with more to be announced. Strait, a Country Music Hall of Fame member who is leading the country music world in these efforts, will perform directly from his benefit concert at San Antonio’s Majestic Theatre.Phone lines, text messaging, and digital donations will be open at the beginning of the show and will conclude one-hour after the show ends. For more information, updates and a link to donate, please visit www.HandInHand2017.com.The Hand in Hand broadcast will be produced by SB Projects and Den of Thieves with Scooter Braun, Bernard ‘Bun B’ Freeman, Allison Kaye, Jesse Ignjatovic and Evan Prager serving as Executive Producers. Additional Executive Producers are Chris Choun, and Lee Lodge with Jordan Brown, Penni Thow and Barb Bialkowski serving as Co-Executive Producers.last_img read more

A whole lotta songs by the same artists on Sirius XM Canada

first_imgCome on, an entire channel devoted to the music of Barbra Streisand? My plans to launch the world’s first Engelbert Humperdinck radio station appear to have hit a snag.“For a channel to go on 24/7, we need a catalogue of 400 songs,” notes Jeff Leake, music programming director at Sirius XM Canada.“If it’s just Engelbert Humperdinck, what 400 songs?’’ Let me think: there was “Release Me” in ’67, “After the Lovin’” in ’76, and uh . . . oh forget it.Two months into my free trial of Sirius Satellite Radio, I’m surprised at my lack of enthusiasm for its robotically curated genre stations (“70s on 7,” “60s on 6”) and tiring personality channels (“The Garth Channel,” “Willie’s Roadhouse”). LEAVE A REPLY Cancel replyLog in to leave a comment Advertisement Advertisementcenter_img Login/Register With: Twitter Advertisement Facebooklast_img read more

Kashechewan in full evacuation mode More coming Saturday

first_img(Members of the Kashechewan First Nation in Ontario wait at the airport prior to boarding. Jason Leroux, APTN)Annette FrancisAPTN National NewsKASHECHEWAN — The sky over the Kashechewan First Nation was busy with planes arriving and then departing as the as the evacuation of elderly, young and sick from the community was in full swing Friday.As a precaution, officials decided to move nearly 1,500 members of Kashechewan hundreds of kilometres to the west to escape the rising water of the Albany river.The first flights out of the community began at 9:00 Friday morning.Families with small babies, toddlers and elders filled the waiting area in the airport much of the day.At points during the day, it was standing room only as residents waited their turn.While the airport was busy, some people refused to leave.“Here we go again,” said Tommy Kooses. Kooses said he is tired of the same threat every spring. This year, he said he’s staying put. “I’m forty years old, I’ve seen this since I was five.”[wooslider slideshow_speed=”2.5″ slider_type=”attachments” limit=”10″] http://bcove.me/pb2e9o8o The problem at the moment is an ice dam 160 kilometres to the north.Given Kashechewan’s poor record of surviving spring floods, officials started talking about leaving weeks ago.Another issue is a government funded dike that was supposed to protect the community from rising waters.center_img But there are serious engineering issues with the dike and it will not be able to hold back the Albany.It’s not clear when residents will return.An ominous sign of what may be coming for this year’s evacuees are about 400 members of Kashechewan still living in Kapuskasing.Their homes are still in the flood plane and have not been repaired since the 2014 flood. “The government’s paying a lot of evacuation costs, said“The government’s paying a lot of evacuation costs,” said Kooses. “It’s costing $20 million every year and it doesn’t need to be like that.  We asked for relocation in 2005.”The second stage of evacuations begins Saturday.500 members will head to Cornwall, and another host community is yet to be determined.afrancis@aptn.ca@aptnafrancislast_img read more

Morocco Stresses Need for Joint Action in Elaborating Arab Social Charter

Rabat-  President of Social, Economic and Environmental Council (CESE) Nizar Baraka underscored, on Monday in Rabat, the need for joint action in the process of elaborating an Arab Social Charter that meets the aspirations of Arab peoples to development and dignified living conditions.Morocco Stresses Need for Joint Action in Elaborating Arab Social Charter.Baraka made the statement at a press briefing following a meeting in Rabat that ended with the announcement to create a league of Arab social and economic councils and similar institutions. During the meeting, Baraka said that the league will play a leading role in promoting participatory democracy and diffusing conflict between the different actors in society.In this regard, Baraka stressed the need for encouraging social dialogue as an indispensable mechanism to reach compromises between the society actors in a way that is conducive to social cohesion in Arab speaking countries. read more

Ongoing insecurity hampering humanitarian efforts in Afghanistan – UN

17 December 2007Having to operate under tighter security restrictions has curtailed the efforts of United Nations agencies and non-governmental organizations (NGOs) in delivering vital humanitarian aid to thousands of Afghans in preparation for winter, the world body’s mission in the country said today. At the end of 2007, humanitarian actors in Afghanistan are operating under much tighter security restrictions – the inevitable consequence of insecurity on the ground – Charlie Higgins of the UN Assistance Mission in Afghanistan (UNAMA) said at a press briefing in Kabul today. “These restrictions curtail our access to communities for humanitarian purposes, whether this is the delivery of relief, or efforts to protect civilians from direct harm during conflict,” stated Mr. Higgins, who heads UNAMA’s humanitarian unit. Mr. Higgins stressed “an unacceptably high risk” to agencies that carry humanitarian deliveries along the main routes in southern and western Afghanistan, as evidenced by a recent attack on a UN World Food Programme (WFP) truck carrying 15 tons of biscuits. The vehicle was looted and then burned, and the driver killed. Despite the difficulties, efforts to move supplies have been “largely successful,” he added, noting that 90 per cent – about 21,000 of the planned 23,000 tons – of the food needed for 326,000 potential beneficiaries this winter has now been delivered by WFP to its partner NGOs across 17 provinces. The UN Children’s Fund (UNICEF), the UN refugee agency (UNHCR) and the World Health Organization (WHO) have also pre-positioned non-food items, including tarpaulins, blankets, jerry cans, kitchen sets, soap, heaters and emergency health kits in the same areas. Mr. Higgins emphasized that Afghanistan has lost much of the “humanitarian space” it had even two or three years ago, which has severely affected the freedom that aid workers need to evaluate essential needs, to monitor the distribution and use of relief, and have a dialogue with the affected people and relevant authorities. “We need to regain the space that humanitarian action needs in order for agencies to deliver the fundamental life-saving services to the population,” he stated. A recent example of this was the three polio vaccination campaigns held in conflict areas such as Helmand province, where the groups fighting the Government agreed to observe “days of tranquillity” and refrain from hindering or attacking the health workers providing the vaccinations, he noted. read more

Lack of funding jeopardizing aid efforts in Kyrgyzstan UN reports

10 August 2010The United Nations and its aid partners today voiced concern that immediate humanitarian needs in Kyrgyzstan will go unmet since they have only received 30 per cent of the $96 million requested to provide life-saving assistance to civilians affected by recent violence. The United Nations and its aid partners today voiced concern that immediate humanitarian needs in Kyrgyzstan will go unmet since they have only received 30 per cent of the $96 million requested to provide life-saving assistance to civilians affected by recent violence. Launched in June, the appeal would enable aid agencies to assist over a six-month period some 300,000 people who have been internally displaced by the conflict that erupted in southern Kyrgyzstan earlier that month, and another 765,000 people who have been affected by the crisis. The clashes between Kyrgyz and ethnic Uzbeks led to a number of deaths and injuries, as well as widespread arson, sexual violence, looting of property and destruction of infrastructure. “The needs are very great. We can address those needs and support the Interim Government and the victims in this crisis, to which any country would struggle to respond single-handedly. But we can do little without the necessary resources,” the Under-Secretary-General for Humanitarian Affairs John Holmes had stated during the launch of the appeal. Aid agencies, through the UN Office for the Coordination of Humanitarian Affairs (OCHA), are working on a funding strategy to try and increase donor support for the appeal, which covers assistance in areas such as food and nutrition, water and sanitation, health, education, and shelter. OCHA also stated in a humanitarian bulletin that the situation in the Central Asian nation remains tense in the southern provinces of Osh and Jalalabad. There are also concerns over reports of serious human rights abuses in the country’s south, including abuse of power, arbitrary detentions and ill-treatment and extortion by law enforcement officials. It has also been reported that persons detained are coerced to sign false confessions and that false evidence is used during search operations, as well as unconfirmed allegations of secret detention facilities. Last month UN High Commissioner for Human Rights Navi Pillay said security forces in southern Kyrgyzstan are responsible for human rights violations, ranging from arbitrary detention to torture, threatening the fragile peace in the area. She added that her staff in Kyrgyzstan has received information suggesting that local authorities are “routinely turning a blind eye” to the illegal arrests, torture and ill-treatment of detainees which result in forced confessions. In addition, the lawyers and families of victims, as well as human rights defenders, are also being threatened and intimidated. The situation spotlights the need for continued monitoring of the human rights situation, especially in the country’s south, said Ms. Pillay, who called for a “thorough international, independent and impartial investigation” into the June violence. read more

SLFP to discuss budget proposals and ETCA

He said that once the views of the party members are obtained it will be discussed with others in the Government in order to reach a compromise on the budget proposals and the ETCA agreement. The Sri Lanka Freedom Party (SLFP) will meet and discuss the budget proposals and the Economic and Technology Co-operation Agreement (ETCA) between India and Sri Lanka.SLFP member and State Minister of Finance Lakshman Yapa Abeywardena said that President Maithripala Sirisena, as head of the SLFP, will discuss the budget and ETCA proposals with the party. He said that if there is anything not suitable for the country in the ETCA agreement then it will be raised by Parliament by the representatives of the people.Abeywardena also said that the opposition has no right to say the Government will be toppled in January next year. He said a Government can be removed only through an election and not through any short-cuts. (Colombo Gazette) The State Minister said that ETCA will be signed only after it is approved by Cabinet and it is discussed in Parliament. read more

UN trade chief urges developed world to open up markets to developing

“The time for rhetoric and political brinkmanship has come and gone,” UN Conference on Trade and Development (UNCTAD) Secretary-General Supachai Panitchpakdi told a regional meeting of Arab trade ministers in Amman, Jordan, ahead of the 6th UN World Trade Organization (WTO) Conference in Hong Kong in December.“There are a few weeks left of tough negotiations in Geneva in which to craft a good package that will lead to the desired outcome in Hong Kong – an outcome that puts development first,” he added, outlining the components of a “fair deal.”These include eliminating market access and entry barriers for products and services of export interest to developing countries, eliminating export subsidies and all trade-distorting support to agriculture including cotton and extending duty-free and quota-free market access for all the least developed countries (LDCs).“The focus must be on the market access and entry conditions that affect developing countries, particularly on agriculture,” Mr. Supachai said, noting the enormous benefits liberalized trade could bring, generating more financing for development than official development assistance (ODA).UNCTAD estimates that liberalization of trade in agriculture, non-agricultural products and temporary movement of persons supplying services and cross-border supply of services could generate up to $310 billion annually, at least half of which could ultimately be captured by developing countries.The distribution of the gains among developing countries is an issue, however, as they are more likely to accrue to those developing countries already enjoying a competitively advantageous position. read more

Manchester terror attack captured on camera by those who were there

first_img Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily  Front Page newsletter and new  audio briefings. Many of those at the concert were young girls, there to capture fond memories of their experience on their mobile phones.When terror struck, those cameras were still rolling.What was meant to be a night to remember, is now one they will wish to forget. On Monday night, a suicide bomber targeted young concertgoers attending an Ariana Grande gig in the Manchester Arena.The ruthless attack claimed the lives of 22 people, including children, with 59 injured.  center_img Footage from those concertgoers uploaded to social media has formed a horrifying picture of the night terror struck Manchester.This is what they saw.last_img read more

Heres What Happened Today Friday

first_imgNEED TO CATCH up? TheJournal.ie brings you a round-up of today’s news…IRELAND Source: Sam Boal via Photocall Ireland UPC are going to become a mobile operator in Ireland in 2015. [TheJournal.ie] Two informants have told IBRC that the Quinn family have over €500 million hidden away.  Protest against the gang rape and murder of two teenage girls. Source: Manish Swarup via AP PressINDIA: Two teen sisters were gang raped and hung from a tree. Two of the four men arrested in relation to the murders are police officers.MALAYSIAN FLIGHT: No debris has been found where underwater pings were detected in the Indian Ocean.AMERICA: Obama’s press secretary has quit. Obama described Jay Carney as one of his closest friends and a great press secretary.INNOVATION  Gardaí have checked 74,500 vehicles for speeding today. The highest speed recorded was 130km in Sligo.  An off duty garda managed to apprehend an armed raider after a bank robbery in Drogheda this afternoon.  PARTING SHOT The swastika is the oldest symbol in the world. Here’s a look at it’s history before World War II.center_img Michael O’Leary has said that Aer Lingus cabin crew are “among the most protected and least overworked groups in Ireland”. It comes as the staff hold a 24 hour strike in a row over rosters.  A court has ruled that people have the right to have links to information about them deleted from Google searches. [TheJournal.ie] INTERNATIONAL  The most popular baby names for 2013 have been revealed. WARNING: They haven’t changed much! Families who have had their discretionary medical card revoked already have been told today that they will not be getting them back. last_img read more

MAME Devs Using Unique Method for Circumventing DRMProtected Arcade Chips

first_img If you’re into playing emulated games, then you know about the Multiple Arcade Machine Emulator. Through MAME, users can enjoy hundreds of arcade games. While there are a great deal of arcade ROMs out there, there are quite a few games that haven’t been emulated due to DRM-protected chips. As reported on Ars Technica, some MAME devs are now getting around this road block by opening up these chips in order to see the raw code written on them.This unusual technique is called “decapping.” This involves physically removing the chip’s “cap” with nitric acid and acetone. This exposes the underlying circuit paths inside of the chip, making it possible to get at the raw code. For some chips, soldering the exposed circuitry allows for dumped files that circumvent DRM. For non-rewritable Mask ROM chips, chip decappers can use a microscope to see the ones and zeroes of the raw code. This is a complicated process — but as the old saying goes — nothing worth doing is ever easy.via Rom Dumping NewsA group calling itself the CapsOff Project is handling the majority of MAME decapping. The group is currently raising money to obtain and decap DRM-protected chips that are in need of repair. This group has also posted instructions on how it decapped titles like Mortal Kombat 4, Bad Dudes, and a number of others.Since all of this takes a considerable amount of time, CapsOff is enlisting help from the community. The team has created a tool that lets people use their eyes to visually decode arcade chips. As described on Ars Technica: “That tool asks users to essentially transcribe 1s and 0s from black-and-white pictures of an ultra-zoomed portion of the chip, overlaid with a guidance grid to help pick out where one bit ends and the next begins.”While emulated games rest in a moral grey area, they do provide a way to preserve classic games. Groups like CapsOff should be commended for doing their part to conserve gaming history. If you’re interested in learning more about this (or if you’re interested in helping), make sure to hit up CapOff’s blog.Let us know what you like about Geek by taking our survey. Stay on target The 8BitDo N30 Pro 2 Controller Is a Great Sequel8BitDo’s New SN30 and SN30 Pro Controllers Pay Homage to the Gameb… last_img read more

Chemo Spray As Alternative to Intravenous Cancer Therapy

first_imgChemotherapy is the treatment of cancer with drugs aimed at destroying diseased cells.But pumping indiscriminate medications through your veins can lead to adverse side effects: fatigue, hair loss, infection, weight changes, mood swings, fertility problems, and a host of other nasty reactions.So, researchers in South Korea developed a sort of “chemo spray”—a new technique that showers a drug like doxorubicin directly onto the tissue surface near the tumor site.Compared to conventional intravenous therapy, the topical spray promises lower risk of systemic toxicity and better healing effects, according to Phys.org.There’s a reason no one has patented this system before: It’s not easy to crack the chemo code. The team, led by Pohang University of Science and Technology professor Hyung Joon Cha, jumped over numerous hurdles to develop their nanoparticle-based spray.Nanoparticles containing chemotherapy drugs and bioengineered mussel adhesive protein are sprayed onto the tissue surface of cancer cells after surgery (via Hyung Joon Cha et al.)They first had to find a way for the particles to stick to tumor cells swimming in bodily fluids. Taking a cue from marine mussels, which produce a special “mussel glue” to adhere to underwater rocks, researchers engineered their own mussel adhesive proteins (MAPs).As an added bonus, the MAPs contain components that allow drug-carrying nanoparticles to enter and destroy cancer cells but bypass healthy ones. Because drug release is pH-responsive, Phys.org reported, highly toxic drugs remain enveloped in the nanoparticles until they reach their acidic destination.The sprayable treatment also features the amino acid DOPA, which helps surface adhesion while depleting the iron in cancer cells, weakening and eventually killing the deadly organisms.“The mussel adhesive protein-based sprayable sticky nanoparticles not only facilitate site-directed administration of drugs via a convenient spraying process during the surgical procedure, but also induce an effective anticancer effect based on the significantly enhanced drug retention and absorption efficiency in the cancerous lesion,” Cha told Phys.org. “Therefore, our nanoparticle-based localized drug delivery system can compensate for the disadvantages of low drug delivery efficiency and systemic toxicity in systemic delivery system.”Moving forward, Cha & Co. hopes to extend their spray method to different types of therapies, in an effort to treat more diseases.A paper on the sprayable cancer therapy was published in a recent issue of the journal ACS Nano.Read More on Cancer: CRISPR’d Cancer Cells Revolt Against Tumors, Does CRISPR Gene Editing Really Cause Cancer?, Cancer-Detecting Cameras Inspired by Animal Eyes, and Can This Mineral Make Bacon Less Carcinogenic?Let us know what you like about Geek by taking our survey.last_img read more

VIDEO Iniesta scores another awesome goal in Japan

first_imgThe ex-Barcelona player has scored two amazing goals in just three matches with Vissel Kobe in the J-LeagueWhen he was in Barcelona, Andrés Iniesta knew how to awe the crowd.His 35 goals in 442 appearances with the Blaugrana were just jewels in the world of football.Now, after being transferred to Vissel Kobe in the Japanese football league, Andrés Iniesta is doing it again.In his third appearance in the J-League, Iniesta’s club hosted Sanfrecce Hiroshima.Anderson Patric Aguiar Oliveira opened the score just 15 minutes after kick-off.Barcelona legend Andres Iniesta credits father for his career Andrew Smyth – August 30, 2019 Andres Iniesta revealed the influence his father has been on his incredible career, which has seen him everything in football for Barcelona and Spain.But two minutes after that, the Spanish footballer would score a beautiful goal.He received a pass at the border of the rival’s area, and from there would shake two defenders off.He then kicked a missile that would end up inside the goal defended by Takuto Hayashi.これぞワールドクラス‼️✨#イニエスタ 選手の2試合連続となるゴールはコチラ??This is World-Class!! Watch Andres Iniesta´s J League second goal.#vissel #神戸vs広島 #WeAreKobe #一致団結#Jリーグ 中継は #DAZN! #iniesta #WorldClass @andresiniesta8 pic.twitter.com/O2QYdiqvSq— ヴィッセル神戸 (@vissel_kobe) August 15, 2018last_img read more

Teen girl accused of running 24hour drug operation out of bedroom window

Vittorioso was arrested and charged with child endangerment, along with other drug offenses. The girl’s boyfriend, Cameron Dawson, was arrested as well.The girl, whose name has not been released, has since been arraigned on drug charges. She was released on personal recognizance.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed. HAVERHILL, MA (WSVN) – A freshman at a Massachusetts high school was arrested after authorities said she was running a 24-hour drug operation out of her bedroom window.Police say the 15-year-old girl was dealing drugs out of her window on the third floor of an apartment on Bellevue Avenue, and according to court documents, she was doing so with her mother’s consent.Customers would routinely walk up the back deck of the apartment, knock on the window and exchange cash for drugs, according to investigators.“She wasn’t that discreet about it. She was having plenty of traffic go up the back,” said neighbor Miles Hafford.A police report indicated that everyone at the building was aware of the operation, including the girl’s mother, 37-year-old Heather Vittorioso.Vittorioso told detectives that she knew her daughter was selling marijuana, but that she was not aware of anything else.Police say officers found cocaine, fentanyl, scales, money and guns inside the apartment, in addition to marijuana. read more

Pixel 3A and 3A XL users complain of phones randomly shutting down

first_imgThe Google Pixel 3A and 3A XL keep shutting down randomly, users say.Google Pixel 3a and 3A XL phones have been randomly shutting down, some users say.According to one post on Reddit, the phone continually dies, and each time it requires a hard reset by holding the power button down for 30 seconds.”I had three shutdowns yesterday, including overnight, causing me to miss my wake alarm,” the post said. “And another shutdown tonight.”Another Reddit user said they called Google support after their Pixel 3a was shutting itself down once a day, and were told to do a factory reset.As reported by Android Police, one Pixel user said whenever they connect to their work Wi-Fi network and let the phone sit for around 10 minutes, it requires a reboot.Google didn’t immediately respond to a request for comment.Issues in previous versions of the Pixel have caused trouble for Google, with the tech giant last week agreeing to a $7.25 million settlement in a class-action lawsuit brought by owners of its original Pixel and Pixel XL smartphones.The affected phones in the settlement were manufactured prior to Jan. 4, 2017. Owners sued Google in February 2018 after alleging they were intentionally sold faulty phones.The original complaint said hundreds of customers had “severe microphone issues.”The Google Pixel 2 XL experienced burn-in issues later in 2017. See It Google Pixel 3A What you should know about Pixel 3A null Walmart 0 $399 Best Buy See It Mobile Tech Industry Phones See it See It $399center_img Sprint Mentioned Above Google Pixel 3A (just black) Tags $399 CNET may get a commission from retail offers. 6:36 Share your voice $398 Now playing: Watch this: News • Google Pixel 3A: Where is AT&T? Review • Pixel 3A review: The cheap phone Google always needed Googlelast_img read more